Home » Research »Cell Engineering and Gene Expression

	Proteomics and Systems Biotechnology
	Protein Glycosylation and Analysis

Introduction of recombinant DNA into heterologous cells for conversion into a protein product or to elicit a functional reponse is a process that defines modern biotechnology. Applied to mammalian cells, gene expression technologies directly underpin pharmaceutical recombinant protein production, the development of gene therapies, (high-throughput) drug screening technologies, as well as diverse primary research and development activity. With respect to the former, the pipeline of biopharmaceuticals in development (greater than 500 are currently in trials) has created an urgent requirement to produce both more productive cell factories and more rapid mammalian cell production processes, both of these enable higher-throughput testing of potential therapeutic proteins.

In our laboratory strategies to rationally engineer the mammalian cell factory are based on both an understanding of cellular function in the in vitro environment obtained via a “systems” approach and the means to re-direct cell function using gene expression or other appropriate technologies.

Researchers:
Dr Stefan Schlatter (s.schlatter@uq.edu.au)
Dr Yun Hee Sung (y.sung@uq.edu.au)
Douglas Galbraith (douglasg@cheque.uq.edu.au)
Marek Mrozkiewicz (marekm@cheque.uq.edu.au)
Nadya Shale (nadyas@cheque.uq.edu.au)