Home » Research » Proteomics and Systems Biotechnology

	Protein Glycosylation and Analysis
	Cell Engineering and Gene Expression

Functional genomic technologies will significantly improve our understanding of cell function in vitro. Accordingly they are likely to underpin our ability to implement rational, knowledge-based strategies for cell engineering and bioprocess development in the future. The most effective approaches will ultimately integrate data streams derived from more than one level of networked cellular organization to enable the derivation of experimentally verifiable predictive models of cell performance. In other words, there is a necessity to combine fundamental biological knowledge with systems engineering using sophisticated functional genomic tools - a “systems biotechnology”.

We are utilizing an advanced proteome analysis platform to characterise the functional molecular phenotype of mammalian cell “factories” producing recombinant monoclonal antibodies. This will help us understand how cells achieve high level productivity and respond to changes in their in vitro environment.

NEW: GS-NS0 Murine Myeloma Clickable Proteome Map

Researchers:
Dr Stefan Schlatter (s.schlatter@uq.edu.au)
Seong Beom Ahn (charliea@cheque.uq.edu.au)
Marek Mrozkiewicz (marekm@cheque.uq.edu.au)
Scott Stansfield (scotths@cheque.uq.edu.au)